Original communication| Volume 4, ISSUE 5, P692-699, November 1938

Acidity of gastric contents after excision of the antral mucosa

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      Total excision of the antral mucosa was accomplished without interrupting the muscular and, in all probability, the nervous continuity of the gastrointestinal tract, and without obvious increase in regurgitation of intestinal contents into the stomach. Complete excision of the antral mucosa did not change the secretory response to the histamine test, but was followed by marked hypoacidity, as determined by a meat test meal. Further investigation is necessary before the results obtained can be ascribed to the absence of a pyloric hormone. However, the method used does offer possibilities of proving whether or not such a hormone exists.
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