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Original communication| Volume 4, ISSUE 5, P762-776, November 1938

Osteopsathyrosis

With a report of three cases
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      Abstract

      Osteopsathyrosis is a disease of the skeleton characterized by marked fragility. It apparently is inherited, although the manner of genetic transmission is not evident.
      The x-ray and microscopic pictures of the bones are relatively constant and unlike any other pathologic entity.
      There is no biochemical evidence to show that the disease is related to pathologic calcium or phosphorus absorption and retention.
      Blue sclera frequently, though not constantly, appears in osteopsathyrosis.
      Treatment of fractures of osteopsathyrotics is the same as that for normal individuals. Rapid healing with abundant callus is the rule.
      The administration of various drugs, vitamins, and extracts has not been demonstrated to affect the growth or structure of the bone in this disease.
      Three cases of osteopsathyrosis treated at the Medical College of Virginia Hospitals are presented.
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