Heparin: A review of its history, chemistry, physiology and clinical applications

References

1. • Reed C.I.
   Practical Uses of Heparin.
   J. Lab. & Clin. Med. 1928; 14: 243
   • Google Scholar
2. • Loucks M.M.
   • Scott F.H.
   Calcium in the Coagulation of Blood.
   Am. J. Physiol. 1929; 91: 27
   • Google Scholar
3. • Holt G.W.
   Heparin in Blood Calcium Analyses.
   in: Proc. Soc. Exper. Biol. & Med. 29. 1931: 315
   • Google Scholar
4. • Van Bergen T.M.
   • Hill R.M.
   The Effect of Added Heparin on Calcium Determinations in Blood Plasma.
   J. Lab. & Clin. Med. 1937; 22: 862
   • Google Scholar
5. • Greisheimer E.M.
   • Arnold A.W.
   Blood Chemistry Changes in Children Produced by Exposure to the Alpine Lamp.
   Am. Rev. Tuberc. 1926; 14: 479
   • Google Scholar
6. • Cantarow A.
   Calcium Metabolism and Calcium Therapy.
   in: Lea and Febiger, Philadelphia1931: 36
   • Google Scholar
7. • Wilander O.
   Complete Blood Analysis of Heparinized Blood.
   Acta Med. Scandinav. 1938; 94: 258
   • Scopus (1)
   • Crossref
   • Google Scholar

8. Mason, M. F.: Unpublished.

   • Google Scholar
9. • Schmidt H.W.
   Über den Einfluss von Antiprothrombin auf die Resistenz der Erythrocyten.
   Ztschr. f. d. ges. Exper. Med. 1933; 92: 351
   • Crossref
   • Google Scholar
10. • Veazie L.
    • Meyer K.F.
    Heparin as an Anticoagulant in the Brucella Phagocytic Index Test.
    in: Proc. Soc. Exper. Biol. & Med. 32. 1935: 1616
    • Google Scholar
11. • Plass E.D.
    • Rourke M.D.
    A New Procedure for Determining Blood Sedimentation Rates.
    J. Clin. Investigation. 1928; 5: 531
    • PubMed
    • Crossref
    • Google Scholar
12. • Rourke M.D.
    • Plass E.D.
    An Investigation of the Various Factors Which Affect the Sedimentation Rate of the Red Blood Cells.
    J. Clin. Invest. 1929; 7: 365
    • PubMed
    • Crossref
    • Google Scholar
13. • Ström J.
    On the Question of Heparin or Citrate for the Sedimentation Reaction.
    Acta Med. Scandinav. 1938; 96: 365
    • Crossref
    • Google Scholar
14. • Zurm K.L.
    • Schenk G.
    • Voss H.
    Untersuchungen zur Wirkung des Heparins.
    Verhandl. d. Deutsch. Gesell. f. inn. Med. Kong. 1933; 45: 436
    • Google Scholar
15. • Enocksson B.
    • Gjertz A.
    • Schnell A.
    • Torgersrund T.
    The Sedimentation Reaction with Heparin.
    Acta Med. Scandinav. 1936; 88: 455
    • Crossref
    • Google Scholar
16. • Zirm K.L.
    • Schenk G.
    Über den Einfluss des Heparins auf die Blutsenkungsgeschwindigkeit.
    Ztschr. f. klin. Med. 1933; 125: 475
    • Google Scholar
17. • Wising P.J.
    The Complement-Fixing Properties of Heparin Salts.
    Acta Med. Scandinav. 1937; 91: 550
    • Scopus (2)
    • Crossref
    • Google Scholar
18. • Wising P.J.
    The Identity of Prothrombin and the Mid-Piece of Complement.
    Acta Med. Scandinav. 1938; 94: 506
    • Scopus (1)
    • Crossref
    • Google Scholar
19. • Howell W.H.
    • McDonald C.H.
    A Note on the Effect of Repeated Intravascular Injections of Heparin.
    Johns Hopkins Hosp. Bull. 1930; 46: 365
    • Google Scholar
20. • Murray D.W.G.
    • Jaques L.B.
    • Perrett T.S.
    • Best C.H.
    Heparin and Thrombosis of Veins Following Injury.
    Surgery. 1937; 2: 163
    • Google Scholar
21. • Jaques L.B.
    The Effect of Intravenous Injections of Heparin in the Dog.
    Am. J. Physiol. 1939; 125: 98
    • Crossref
    • Google Scholar
22. • Mason E.C.
    The Production and Prevention of Experimental Thrombosis and Pulmonary Embolism.
    Surg. Gynec. & Obst. 1924; 39: 421
    • Google Scholar
23. • Shionoya T.
    Studies in Experimental Extracorporeal Thrombosis. III. Effects of Certain Anticoagulants (Heparin and Hirudin) on Extracorporeal Thrombosis and on the Mechanism of Thrombus Formation.
    J. Exper. Med. 1927; 46: 19
    • Scopus (15)
    • PubMed
    • Crossref
    • Google Scholar
24. • Shionoya T.
    Studies in Extracorporeal Thrombosis. IV. Effects of Certain Physical and Mechanical Factors on Extracorporeal Thrombosis With and Without Use of Anticoagulants.
    J. Exper. Med. 1927; 46: 957
    • Scopus (1)
    • PubMed
    • Crossref
    • Google Scholar
25. • Shionoya T.
    Studies in Extracorporeal Thrombosis. V. Influence of Certain Chemical Substances on Extracorporeal Thrombosis With Special Reference to the Efficacy of a Combination of Heparin and Magnesium Sulfate.
    J. Exper. Med. 1927; 46: 963
    • PubMed
    • Crossref
    • Google Scholar
26. • Best C.H.
    • Cowan C.
    • MacLean D.L.
    Heparin and the Formation of White Thrombi.
    Science. 1937; 85: 338
    • Scopus (8)
    • PubMed
    • Crossref
    • Google Scholar
27. • Best C.B.
    • Cowan C.
    • MacLean D.L.
    Heparin and the Formation of White Thrombi.
    J. Physiol. 1938; 92: 20
    • PubMed
    • Google Scholar
28. • Murray G.D.W.
    • Best C.H.
    The Use of Heparin in Thrombosis.
    Ann. Surg. 1938; 108: 163
    • PubMed
    • Crossref
    • Google Scholar
29. • Solandt D.Y.
    • Best C.H.
    Heparin and Coronary Thrombosis in Experimental Animals.
    Lancet. 1938; 2: 130
    • Scopus (6)
    • Abstract
    • Google Scholar
30. • Best C.H.
    Heparin and Thrombosis.
    Brit. M. J. 1938; 2: 977
    • Scopus (8)
    • PubMed
    • Crossref
    • Google Scholar

31. Blalock, A., and Cressman, R.: Personal Communication.

    • Google Scholar
32. • Widström G.
    • Wilander O.
    Treatment of Experimental Pleurisy in Rabbits with Heparin.
    Acta Med. Scandinav. 1936; 88: 434
    • Crossref
    • Google Scholar
33. • Nyiri W.
    Experimentelle Untersuchungen über gekrcutze Bluttransfusion bei Urämie.
    Arch. f. Exper. Path. u. Pharmakol. 1926; 116: 117
    • Scopus (1)
    • Crossref
    • Google Scholar
34. • Thalhimer W.
    Experimental Exchange Transfusions for Reducing Azotemia. Use of Artificial Kidney for This Purpose.
    in: Proc. Soc. Exper. Biol. & Med. 37. 1938: 641
    • Google Scholar
35. • Thalhimer W.
    • Solandt D.Y.
    • Best C.H.
    Experimental Exchange Transfusion Using Purified Beparin.
    Lancet. 1938; 2: 554
    • Scopus (11)
    • Abstract
    • Google Scholar
36. • Solandt D.Y.
    • Robinson F.L.
    J. Sc. Instrum. 1938;
    • Google Scholar
37. • Kyes P.
    • Strauser E.R.
    Heparin Inhibition of Anaphylactic Shock.
    J. immunol. 1926; 12: 419
    • Google Scholar
38. • Biedl A.
    • Kraus R.
    Experimentelle Studien über Auaphylaxie.
    Wien. klin. Wchnschr. 1909; 2: 363
    • Google Scholar
39. • Gahringer J.E.
    The Sensitization of Pigeons to Foreign Proteins.
    J. Immunol. 1926; 12: 477
    • Google Scholar
40. • Reed C.I.
    • Lamson R.W.
    The Influence of Heparin on the Course of Anaphylaxis in the Guinca Pig.
    J. Immunol. 1927; 13: 433
    • Google Scholar
41. • Van de Carr F.R.
    • Williams O.B.
    Further Studies on the Influence of Heparin on Anaphylactic Shock in the Guinea Pig.
    J. Immunol. 1928; 15: 13
    • Google Scholar
42. • Williams O.B.
    • van de Carr F.R.
    The Effect of Heparin on Anaphylactic Shock in Guinea Pigs.
    in: Proc. Soc. Exper. Biol. & Med. 24. 1927: 798
    • Google Scholar
43. • Doxiades L.
    • Lemke H.
    Beeinflussung des Anaphylaktischen Shocks beim Meerschweinchen durch Heparin.
    Klin. Wchnschr. 1937; 16: 1061
    • Crossref
    • Google Scholar
44. • Mills C.A.
    The Relation of Blood Clotting to Anaphylactic Shock.
    Chinese J. Physiol. 1927; 1: 439
    • Google Scholar
45. • Hanzlik P.J.
    • Butt E.M.
    • Stockton A.B.
    Reciprocal Action of the Crop Muscles in Anaphylactic Shock with a Note on the Effects of Heparin.
    J. Immunol. 1927; 13: 409
    • Google Scholar
46. • Hyde R.E.
    Heparin Inhibition of Anaphylactic Shock.
    Am. J. Hygiene. 1927; 7: 614
    • Google Scholar
47. • Loewenthal H.
    Ueber die Beziehungen der Blutgerinnung zum Anaphylaktischen Shock.
    Ztschr. f. Immunitätsforsch. u. exper. Therap. 1927; 54: 138
    • Google Scholar
48. • Bradley J.D.
    • Dragstedt C.A.
    Effect of Heparin on Acute Anaphylactic Shock.
    in: Proc. Soc. Exper. Biol. & Med. 31. 1933: 532
    • Google Scholar
49. • Klopstock F.
    Ueber den Einfluss von Heparin und Germanin auf Immunreaktionen.
    Ztschr. f. Immunitätsforsch. u. exper. Therap. 1932; 75: 348
    • Google Scholar
50. • Waud R.R.
    Sudden Transitory Reduction in the Viscosity of the Blood as a Cause of the Fall in Blood Pressure in Shock.
    Am. J. Physiol. 1927; 81: 160
    • Google Scholar
51. • Reed C.I.
    Further Investigations on the Reported Antianaphylactic Action of Heparin.
    J. Immunol. 1930; 18: 181
    • Google Scholar
52. • Waters E.T.
    • Markowitz J.
    • Jaques L.B.
    Anaphylaxis in the Liverless Dog and Observations on the Anticoagulant of Anaphylactic Shock.
    Science. 1938; 87: 582
    • Scopus (5)
    • PubMed
    • Crossref
    • Google Scholar
53. • Roome N.W.
    • Wilson H.
    Experimental Shock. The Effects of Extracts From Traumatized Limbs on the Blood Pressure.
    Arch. Surg. 1935; 31: 361
    • Crossref
    • Google Scholar
54. • Craciun E.C.
    Heparin-Plasma as Stock Plasma for Tissue Cultures.
    Bull. Johns Hopkins Hosp. 1926; 38: 327
    • Google Scholar
55. • Goerner A.
    The Influence of Anti-Clotting Agents on Transplantation and Growth of Tumour Tissue.
    J. Lab. & Clin. Med. 1931; 16: 369
    • Google Scholar
56. • Fischer A.
    • Parker R.C.
    Dauerzüchtung in vitro ohne Wachtums-beschleunigung.
    Arch. f. exper. Zellforsch. 1929; 8: 325
    • Google Scholar
57. • Zakrzewski Z.
    Die Rolle des Prothrombins und Heparins bei der Proliferation und Differenzierung von Geweben. Untersuchungen in Vitro.
    Klin. Wchnschr. 1932; 11: 113
    • Scopus (1)
    • Crossref
    • Google Scholar
58. • Zakrzewski Z.
    Die Rolle des Prothrombins und Heparins bei der Proliferation und Differenzierung von Geweben. Untersuchungen in Vitro.
    Arch. f. Exper. Zellforsch. 1932; 13: 152
    • Google Scholar
59. • Zakrzewski Z.
    Untersuchungen über den Einfluss von Heparin auf das Wachstum von Sarkomzellen in Vitro.
    Klin. Wchnschr. 1932; 11: 158
    • Crossref
    • Google Scholar
60. • Zakrzewski Z.
    Untersuchungen über den Einfluss von Heparin auf das Wachstum der Sarkomzellen in Vitro.
    Ztschr. f. Krebsforsch. 1932; 36: 513
    • Scopus (3)
    • Crossref
    • Google Scholar
61. • Zakrzewski Z.
    Die Rolle des Prothrombins und Heparins bei der Proliferation und Differenzierung von Geweben. II. Untersuchungen in vitro.
    Klin. Wchnschr. 1933; 12: 1658
    • Crossref
    • Google Scholar
62. • Fischer A.
    • Nyström P.
    Heparin als Wachstumhemmender Stoff.
    Biochem. Ztschr. 1933; 262: 364
    • Google Scholar
63. • Von Jancsó N.
    Pharmakologische Beeinflussung des Reticuloendothelials.
    Klin. Wchnschr. 1931; 10: 537
    • Scopus (2)
    • Crossref
    • Google Scholar
64. • Hillman L.M.
    • Moore R.A.
    • Andrus W.DeW.
    Blood Heparin and Lipoid Amino Nitrogen in Experimental Jaundice.
    in: Proc. Soc. Exper. Biol. & Med. 36. 1937: 176
    • Google Scholar
65. • Mahorner H.R.
    • Ochsner A.
    Bactericidal Effect of Hirudin and Heparin. II. Growth of Organisms in Blood Rendered Incoagulable with Heparin and Hirudin.
    Arch. Surg. 1935; 31: 371
    • Crossref
    • Google Scholar
66. • Ochsner A.
    • Mahorner H.R.
    Bactericidal Effect of Hirudin and Heparin. I. Intravenous Injection of Hirudin and of Heparin and Leeching in Experimental Bacteremia.
    Arch. Surg. 1935; 31: 308
    • Crossref
    • Google Scholar
67. • Yankovsky W.D.
    Sur les Propriétés Physiologiques de l'Heparine Howell.
    J. de physiol. et de path. gén. 1930; 28: 579
    • Google Scholar
68. • Best C.H.
    Heparin and Thrombosis. The Present Situation.
    J. A. M. A. 1938; 110: 118
    • Google Scholar
69. • Mason E.C.
    A Note on the Use of Heparin in Blood Transfusion.
    J. Lab. & Clin. Med. 1924; 10: 203
    • Google Scholar
70. • Godlowski Z.
    Die Heparin (Antiprothrombin) Verwendung zwecks Funktionsprüfung des Menschlichen Retikulo-endothelian Systems.
    Wien. med. Wchnschr. 1932; 82: 1429
    • Google Scholar
71. • Hedenius P.
    • Wilander O.
    The Influence of Intravenous Injections of Heparin in Man on Time of Coagulation.
    Acta Med. Scandinav. 1936; 88: 443
    • Scopus (12)
    • Crossref
    • Google Scholar
72. • Hedenius P.
    An Apparatus for Determining the Coagulation Time of the Blood.
    Acta Med. Scandinav. 1936; 88: 440
    • Crossref
    • Google Scholar
73. • Reed C.L.
    • Lamson R.W.
    Heparin. II. Investigation of Possible Antigenic Action.
    in: Proc. Soc. Exper. Biol. & Med. 23. 1926: 656
    • Google Scholar
74. • Skold E.
    Heparin bei Bluttransfusion.
    Acta Med. Scandinav. 1936; 88: 450
    • Crossref
    • Google Scholar
75. • Clemens J.
    Über Heparin und seine Verwendung für die indirekte Blutübertragung.
    Zentralbl. Chir. 1938; 65: 809
    • Google Scholar
76. • Clemens J.
    Die Anwendung des Heparins zu Blutübertragungen.
    Deutche med. Wchnschr. 1938; 64: 1043
    • Crossref
    • Google Scholar
77. • Heim W.
    Die Indirekte Bluttransfusion mit “Vetren”.
    München med. Wchnschr. 1938; 85: 1157
    • Google Scholar
78. • Knoll H.
    • Schürch O.
    Blood Transfusion With Heparin.
    Lancet. 1938; 1: 1387
    • Abstract
    • Google Scholar
79. • Hedenius P.
    A New Method of Blood Transfusion.
    Acta Med. Scandinav. 1936; 89: 263
    • Scopus (2)
    • Crossref
    • Google Scholar
80. • Crafoord C.
    Preliminary Report on Postoperative Treatment With Heparin as a Preventive of Thrombosis.
    Acta Chir. Scandinav. 1937; 79: 407
    • Google Scholar
81. • Bancroft F.W.
    • Stanley-Brown M.
    • Chargaff E.
    Postoperative Thrombosis and Embolism.
    Ann. Surg. 1937; 106: 868
    • PubMed
    • Crossref
    • Google Scholar
82. • Holmin N.
    • Ploman K.G.
    Thrombosis of Central Vein of Retina Treated With Heparin.
    Lancet. 1938; 1: 664
    • Scopus (15)
    • Abstract
    • Google Scholar
83. • Boström C.G.
    • William-Ollson L.
    Thrombosis of Central Vein of Retina Successfully Treated With Heparin. A Second Case.
    Lancet. 1938; 2: 78
    • Abstract
    • Google Scholar
84. • Magnusson J.H.
    Thrombosis of the Posterior-Inferior Cerebellar Artery (Wallenberg Syndrome).
    Lancet. 1938; 1: 666
    • Google Scholar
85. • Haas Gr.
    Über Blutwaschung.
    Klin. Wchnschr. 1928; 7: 1356
    • Scopus (35)
    • Crossref
    • Google Scholar
86. • Emile-Weil P.
    L'Hémophile, Pathogenie et Serotherapie.
    Presse méd. 1905; 13: 673
    • Google Scholar
87. • Fuchs H.J.
    • von Falkenhausen M.
    Über das Wesen der Hämophilie.
    Klin. Wchnschr. 1930; 9: 928
    • Crossref
    • Google Scholar
88. • Fuchs H.J.
    Über das Wesen der Hämophilie.
    Klin. Wchnschr. 1930; 9: 928
    • Crossref
    • Google Scholar
89. • Howell W.H.
    Note Upon the Presence of Heparin in Normal and Hemophilic Blood.
    Am. J. Physiol. 1926; 77: 680
    • Google Scholar
90. • Evans P.S.
    • Howell W.H.
    Does Hemophilic Blood Contain an Excess of an Anticoagulant?.
    Am. J. Physiol. 1931; 98: 131
    • Google Scholar
91. • Fuchs H.J.
    Wichtige Methodische Einzelheiten bei Blutgerinnungsunter-suchungen sowie eine Isolierungsmethodik des physiologischen gerinnung-shemmenden Faktors (Antiprothrombin) aus Blut und Gewebe.
    Biochem. Ztschr. 1930; 222: 470
    • Google Scholar
92. • Godlowski Z.
    Die Heparin (Antiprothrombin) Verwendung zwecks Funktionsprüfung des Menschlichen Retikulo-endothelial Systems.
    Wien. med. Wehnschr. 1933; 83: 1034
    • Google Scholar
93. • Stuber B.
    • Lang K.
    Untersuchungen zur Lehre von der Blutgerinnung. XX. Über die Hemmung der Blutgerinnung durch Heparin.
    Biochem. Ztschr. 1929; 212: 16
    • Google Scholar