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Abstract
The three cases confirm the general experience of others in regard to the treatment
of these ulcers. Ordinary methods of treatment are usually of no avail and although
these lesions, while under treatment, may tend to regress in one area while progressing
in another or even regress and remain dormant for a time, they eventually will progress
until they destroy the patient unless something radical is done. Before Meleney introduced
the zinc peroxide treatment, there were only three or four cases reported in the literature
that had recovered without radical excision of the ulcers,
In our three cases zinc peroxide alone was powerless to control the lesion, but, when
used in conjunction with surgery, it seemed to be of definite benefit, It was never
able to stop undermining of skin, ribs, or muscles alone but once these infected areas
were completely removed, the material appeared to prevent recurrence, We have no proof
of its mode of action and are unable to decide whether it acts specifically against
anaerobic organisms by liberating oxygen, as Meleney believes ,30 or whether it merely provides a comfortable nonadherent dressing which promotes drainage
and requires such meticulous care of the wound that healing results.
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Article info
Publication history
Received:
November 25,
1938
Identification
Copyright
© 1939 Published by Elsevier Inc.
