This paper is only available as a PDF. To read, Please Download here.
In a study of 30 patients with miscellaneous diseases and prothrombin deficiency, the following impressions were obtained:
- 1.1. 2-methyl-1,4-naphthoquinone, its dipropionyl derivative, and its sodium bisulfite derivative have satisfactory vitamin K-potency taken orally or parenterally in dosage of 1 to 4 mg. daily.
- 2.2. No evidence of toxicity was seen in giving as much as 20 mg. of 2-methyl-1,4-naphthoquinone intravenously in one dose.
- 3.3. The prothrombin response to treatment appears within twenty-four hours and lasts less than a week after vitamin K therapy is ended. The daily administration of vitamin K is desirable in treating hypoprothrombinemia.
- 4.4. Prothrombin deficiency refractory to treatment may be seen in severe liver damage and in chronic sepsis.
- 5.5. The effectiveness of 2-methyl-1,4-naphthoquinone taken by mouth is increased by taking deoxycholic acid or bile salts, even in the absence of jaundice.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Surgery
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- The Synthesis of Vitamin K.Science. 1940; 91: 31
- Vitamin K-Active Derivatives of 2-Methyl-1,4-Naphthoquinone.J. Am. Chem. Soc. 1940; 62: 430
- The Vitamin K Activity of Naphthoquinones.J. Am. Chem. Soc. 1940; 62: 430
- Treatment of Hypoprothrombinemia: Use of Various Synthetic Compounds Exhibiting Antihemorrhagic Activity (Vitamin K Activity).in: Proc. Staff Meet., Mayo Clin. 15. 1940: 69
- Correction of Prothrombin Deficiencies by Means of 2-Methyl-1,4-Naphthoquinone Injected Intramuscularly.J. A. M. A. 1940; 114: 1336
- Quantitative Study on Blood Clotting: Prothrombin Fluctuations under Experimental Conditions.Am. J. Physiol. 1936; 114: 667
- Prothrombin and Vitamin K Therapy.New England J. Med. 1939; 221: 403
Personal communication from Dr. Carl Nielsen.
Personal communication from Dr. A. Black.
- Prothrombin Deficiency and the Effects of Vitamin K in Obstructive Jaundice and Biliary Fistula.Ann. Surg. 1939; 109: 588
Received: May 1, 1940
© 1941 Published by Elsevier Inc.