Oral and parenteral use of synthetic vitamin K-active substances in hypoprothrombinemia

John D. Stewart, M.D.
John D. Stewart
Affiliations
From the Surgical Laboratories of the Harvard Medical School at the Massachusetts General Hospital Boston, Mass., USA
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Abstract

In a study of 30 patients with miscellaneous diseases and prothrombin deficiency, the following impressions were obtained:

1.
1. 2-methyl-1,4-naphthoquinone, its dipropionyl derivative, and its sodium bisulfite derivative have satisfactory vitamin K-potency taken orally or parenterally in dosage of 1 to 4 mg. daily.
2.
2. No evidence of toxicity was seen in giving as much as 20 mg. of 2-methyl-1,4-naphthoquinone intravenously in one dose.
3.
3. The prothrombin response to treatment appears within twenty-four hours and lasts less than a week after vitamin K therapy is ended. The daily administration of vitamin K is desirable in treating hypoprothrombinemia.
4.
4. Prothrombin deficiency refractory to treatment may be seen in severe liver damage and in chronic sepsis.
5.
5. The effectiveness of 2-methyl-1,4-naphthoquinone taken by mouth is increased by taking deoxycholic acid or bile salts, even in the absence of jaundice.

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Received: May 1, 1940

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