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Original communication| Volume 13, ISSUE 2, P316-321, February 1943

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Bleeding time in mice following the oral administration of 3,3′-methylene-bis-(4-hydroxycoumarin)

DOI:https://doi.org/10.5555/uri:pii:S0039606043904441
Bleeding time in mice following the oral administration of 3,3′-methylene-bis-(4-hydroxycoumarin)
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      Abstract

      • 1.
        1. A prothrombin time test was developed in mice, using 0.1 c.c. heart blood. Prothrombin time values ranged from 15 to 28 seconds and averaged 22.4 seconds.
      • 2.
        2. Following oral administration of 60 to 100 mg. per kg. of 3,3′-methylene-bis-(4-hydroxycoumarin) over a period of three days, the bleeding time was prolonged in some of the mice.
      • 3.
        3. Comparison of bleeding time with coagulation and prothrombin times showed a lack of correlation in many of the mice. Some animals had prolonged bleeding times with normal coagulation and prothrombin times, while others had prolonged coagulation and prothrombin times with a normal bleeding time.
      • 4.
        4. Hematomas were more frequently found in mice with prolonged bleeding time or prothrombin time than in mice with normal values.
      • 5.
        5. The relation of bleeding time and prothrombin time to hemorrhagic tendency was discussed. It appeared that still other factors which were discussed are involved in hemostasis.
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      Article info

      Publication history

      Received: May 4, 1942

      Footnotes

      ☆Aided in part by a grant from the Dr. Herbert L. Celler Foundation, New York, N. Y.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:S0039606043904441

      Copyright

      © 1943 Published by Elsevier Inc.

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