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Abstract
Experimental studies have shown that fibrin foam with thrombin is an effective absorbable
hemostatic agent in the liver, peritoneal cavity, abdominal wall, kidney, and lung.
In each of these locations the absorption of the material is accompanied by only slight
tissue reaction.
Clinical appraisal of fibrin foam with thrombin as an absorbable hemostatic agent
in general surgery has been carried out in 240 patients. It has proved effective in
controlling oozing surfaces and venous bleeding under a wide variety of circumstances,
including wounds in patients with hemophilia.
The use of fibrin foam with thrombin should not replace the careful control of bleeding
by means of meticulous dissection and adequate placing of sutures. It should be reserved
for those particular situations in which an absorbable hemostatic agent is desirable
to prevent the injuring of vital anatomic structures or to control oozing which is
not easily stopped by conventional methods, as in the beds of tumors and the cut surface
of parenchymatous organs.
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References
- Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation. I. The Characterization of the Protein Fractions of Human Plasma.J. Clin. Investigation. 1944; 23: 417-432
- Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation. XV. The Proteins Concerned in the Blood Coagulation Mechanism.J. Clin. Investigation. 1944; 23: 557-565
- Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation. XX. The Development of Fibrin Foam as a Hemostatic Agent for Use in Conjunction With Human Thrombin.J. Clin. Investigation. 1944; 23: 586-590
- The Use of Products Prepared From Human Fibrinogen and Human Thrombin in Neurosurgery: Fibrin Foams as Hemostatic Agents; Fibrin Films in Repair of Dural Defects and in Prevention of Meningocerebral Adhesions.J. Neurosurg. 1944; 1: 23-39
- Studies on Fibrin Foam as a Hemostatic Agent in Neurosurgery, With Special Reference to Its Comparison With Muscle.J. Neurosurg. 1944; 1: 171-181
- Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation. XXI. The Use of Fibrin Foam as a Hemostatic Agent in Neurosurgery. Clinical and Pathological Studies.J. Clin. Investigation. 1944; 23: 591-596
- Clinical Use of Products of Human Plasma Fractionation. III. The Use of Products of Fibrinogen and Thrombin in Surgery.J. A. M. A. 1944; 126: 680-685
- Absorbable Cotton, Paper and Gauze (Oxidized Cellulose).Ann. Surg. 1943; 118: 116-126
- Hemostasis With Absorbable Gauze (Oxidized Cellulose).Ann. Surg. 1944; 120: 181-198
Article info
Publication history
Received:
April 11,
1945
Footnotes
☆This work has been carried out under contract recommended by the Committee on Medical Research between the Office of Scientific Research and Development and Harvard University.
☆☆This paper is No. 33 in the “Studies on Plasma Proteins” of the Harvard Medical School, on products developed by the Department of Physical Chemistry from blood collected by the American Red Cross.
Identification
Copyright
© 1945 Published by Elsevier Inc.
