Original communication| Volume 24, ISSUE 2, P392-400, August 1948

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Inhalation of micropowdered penicillin and streptomycin in the prevention of postopeative pulmonary infection

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      The incidence of postoperative pulmonary infections can be greatly reduced by the prophylactic administration of penicillin and/or streptomycin. The administration of these materials by inhalation in the micropowdered form has been found to be a very satisfactory method, and relatively small doses of the chemotherapeutic agent are required.
      Bacteria present in the upper respiratory tract preoperatively are important factors in the genesis of postoperative pulmonary infection. Reduction of respiratory complications following upper abdominal and thoracic surgery can be accomplished by measures which minimize atelectasis and promote pulmonary ventilation in conjunction with inhalation chemotherapy.
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