Abstract
Background: The burgeoning influence of managed care in transplantation, coupled with a shrinking
health-care dollar, has placed most transplant programs under intense pressure to
cut costs. We undertook a retrospective cost-identification analysis to determine
what clinical variables influenced financial outcomes after orthotopic cadaver liver
transplants (OLTx). Methods: Fifty patients receiving 53 transplants between April 1995 and November 1996 were
reviewed. Clinical data were obtained from our institution's transplant database,
and total costs (not charges) for the transplant admission and the 6 months after
transplant were obtained with use of an activity-based cost accounting system (HBOC
Trendstar, Atlanta, Ga). Results: The average total cost of second transplants (n = 5) was $97,262 greater than for
first transplants (n = 48, P < .05). Patients transplanted initially as United Network for Organ Sharing (UNOS)
status 2 (n = 20) incurred average costs that were $51,762 higher than for patients
transplanted as UNOS status 3 (n = 28, P = .008). Patients with a major bacterial or fungal infection (n = 28) incurred average
costs $46,282 higher than recipients who were infection free (n = 22, P = .02). Multivariate analysis demonstrated that only length of stay, retransplantation,
and postoperative dialysis were significantly and independently correlated with costs
(r2 = .605). When the model was repeated with preoperative variables alone, only UNOS
status was significantly correlated with 6-month total costs (P = .006, r2 = .16). Conclusions: Length of stay is the most important determinant of costs after OLTx. Rational strategies
to design cost-effective protocols after OLTx will require further studies to truly
define the cost of various morbidities and outcomes after OLTx. (Surgery 1999;125:217-22.)
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The distinction between costs and charges.Arch Intern Med. 1982; 96: 102-109
- Measuring the costs of nosocomial infections: methods for estimating economic burden on the hospital.Am J Med. 1991; 91: 32S-38S
- Where are the costs in perioperative care? Analysis of hospital costs and charges for inpatient surgical care.Anesthesiology. 1995; 83: 1138-1144
- Hospital cost accounting: who's doing what and why.Health Care Manage Rev. 1990; 15: 73-78
- A general approach to costing procedures in ancillary departments.Top Health Care Fin. 1987; 13: 32-47
- Graft and patient survival rates.in: UNOS 1996 annual report. US Department of Health and Human Services, Washington1997: 144
- Preoperative predictors of resource utilization in liver transplantation.in: Clinical transplants 1995. University of California, Los Angeles, Los Angeles1995: 315-322
- The impact of surgical complications after liver transplantation on resource utilization.Ann Surg. 1997; 132: 1098-1103
- Cytomegalovirus disease is associated with increased cost and hospital length of stay among orthotopic liver transplant recipients.Transplantation. 1997; 63: 1595-1601
- Bottoms up accounting systems: a superior method for controlling health care costs.Mod Healthcare. 1977; 17: 50-55
- Infectious complications after OKT3 induction in liver transplantation.Liver Transplant Surg. 1997; 3: 563-570
- 1997 Report of center specific graft and patient survival rates.Department of Health and Human Services, Washington1997
- The clinical-economic trial: promise, problems and challenges.Controlled Clin Trials. 1995; 16: 377-394
- A guide to the economic analysis of clinical practices.JAMA. 1989; 262: 2879-2886
- Risk of postoperative infection after liver transplantation: a univariate and stepwise logistic regression analysis of risk factors in 150 consecutive patients.Clin Transplantation. 1992; 46: 443-449
- Apache-II-scoring in the liver transplant recipient.Intensive Care Med. 1997; 18: 60-61
- Influence of selected patient variables and operative blood loss on six-month survival following liver transplantation.Semin Liver Dis. 1985; 5: 385-393
- A cost-outcome analysis of retransplantation: the need for accountability.Transplant Rev. 1993; 7: 163-168
- Use of of low- dose OKT3 as induction therapy in liver transplantation.Transplantation. 1998; 65: 577-580
- The cost of rejection in liver allograft recipients.Transplant Proc. 1998; 30: 1500-1501
- Cytomegalovirus immune globulin prophylaxis in liver transplantation: a randomized, double-blind, placebo-controlled trial. The Boston Center for Liver Transplantation.Ann Intern Med. 1993; 119: 984-991
- High-dose acyclovir compared with short-course preemptive ganciclovir therapy to prevent cytomegalovirus disease in liver transplant recipients.Ann Intern Med. 1994; 120: 375-381
- Randomized comparison of ganciclovir and high-dose acyclovir for long-term cytomegalovirus prophylaxis in liver-transplant recipients.Lancet. 1995; 346: 69-74
- Cytomegalovirus prophylaxis in solid organ transplant recipients.Transplantation. 1996; 61: 1279-1289
- A double-blind, randomized placebo-controlled trial of prostaglandin E1 in liver transplantation.Hepatology. 1995; 21: 366-372
Article info
Publication history
Accepted:
August 10,
1998
Footnotes
☆Reprint requests: James F. Whiting, MD, University of Cincinnati Department of Surgery, 231 Bethesda Ave, PO Box 67055, Cincinnati, OH 45267-0558.
Identification
Copyright
© 1999 Mosby, Inc. Published by Elsevier Inc. All rights reserved.